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KMID : 0370220030470060444
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Yakhak Hoeji
2003 Volume.47 No. 6 p.444 ~ p.459
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HPLC Determination and Pharmacokinetic Profile of Ethosuximide in Korean Subjects
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배정우/Bae JW
김지홍/양상인/김현경/장춘곤/한혜원/박영서/손의동/Kim JH/Yang SI/Kim HK/Jang CG/Han HW/Park YS/Sohn UD
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Abstract
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Ethosuximide is an oral anticonvulsantic agent used in the first choice anti-absence seizure drug. The purpose of this study was to assess the pharmacokinetic profile of the e thosuximide in healthy Korean volunteers and to develop the efficient assay method of ethosuximide in human plasma. The pharmacokinetics of ethosuximide administered orally was evaluated after a dose of 500 mg. Ethosuximide was assayed from plasma by a specific HPLC method reading absorbance at 195 nm. AUC was 1222±160 μg/ml·hr, Cmax 14.21±1.74 μg/ml, Tmax 1.06±0.62 hr and half-life 77.83±12.46 hr. The half-life in Korean was longer than, in Caucasian (53~56 hr).
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